1. If you can, it is wise to place some newspaper beneath your work area. I also suggest baby wipes to help you out in case of any spills or dripping. Barely damp paper towels are also an option if you do not have baby wipes.
2. Put a needle on each of your syringes. Leave needle covers on whenever not in use. I suggest marking each syringe with a way for you to know which color is used in each syringe. If you wash them well enough, it will not matter. However, my thought is why take the chance of the inks mixing at all.
3. The gloves are of course optional. I personally do not use them, but my fingernails are typically proof that I work in inks. Use your own discretion for this.
4. If you are starting with prefilled cartridges, there will likely be a label on the top of the cartridge. It's time to take it off. Completely remove this label to expose two sets of holes on the top of the cartridge. The top holes are smaller, and called the vent holes (these are under the yellow tape when the cartridge is new). The holes in the middle are the ones that hold a plug. These are larger, and located in the middle of the top side of the cartridge. Both the vent hole and the fill holes go to the same location inside the cartridge, but for the sake of not damaging the cartridges, avoid attempting to fill from the vent holes.
5. Take your tape and tape all openings, specifically the bottom holes, so that only one opening at a time will be exposed. Many people are using an electric tape for the bottom holes and rather than removing them when you are finished refilling, they simply puncture the electric tape as if it were a new set of cartridges.
6. Your cartridges probably come with small plugs that go into the fill holes. There is no need to tape over these as long as they remain plugged. Best practice is to only remove one plug at a time right before refilling that chamber and immediately re-plugging it.
7. Open your color that you are filling first. We suggest doing only one color at a time to avoid the possibility of one ink falling into another colors compartment.
8. Hint: If you have an OEM ink cartridge handy, place the one you are going to fill beside it. Look at the locations of each color and either mark the empty cartridge with a reminder such as M=magenta, Y=yellow, C=cyan so that you will not accidentally put the incorrect ink into the tank. If for some reason you HAVE put the wrong colors into a chamber, there is no salvaging the cartridges. Time to buy another set...groan.
9. Draw into your syringe in equal increments (possibly 5 or 10 ml at a time) the ink color you are working with. Each printer cartridge usually will have a different capacity amount. You will learn this as you go and will get a "feel" for it.
10. Air pockets can keep you from getting your cartridge to full capacity. You will find that AIR is your worst enemy with filling/refilling cartridges.
11. Slowly and carefully, insert the needle into the fill hole for the proper color. Place it fairly deep into the cartridge. Be cautious not to force the needle.
12. Squeeze the ink gradually into the cartridge, being careful not to fill too quickly so that it overflows or introduces more air than is already inside the cartridge. If it does overflow, simply take a barely damp wet wipe and blot it off.
13. When finished with each color, place a rubber stopper or tape over the hole you just filled and make certain that it is airtight.
14. Continue to fill the other colors and the black tanks in the same manner. One at a time, replacing tape as necessary.
15. Let cartridges sit for at least 30-60 minutes before attempting to place them into your printer.
16. It is common for there to be ink leaking from the bottom for several minutes after you remove the bottom tape (Only if this is a refill. A first time fill will not have the holes punctured yet).
17. Hint: It is suggested that you do not set them on anything absorbent such as paper towels that would actually draw the ink out of the cartridge. If you choose to, many people have experimented with leaving the tape on the bottom and treating it like a new cartridge (puncturing the tape when installing as mentioned above).  I have not personally done this while I was refilling, but they tell me that it works great.  They use a good quality black electric tape and simply remove it and replace it with a new strip with each refill.
18. Place the cartridges back into the printer. It is recommended that wait a minimum of 3-6 hours, but I suggest overnight to let the cartridge fully re-stabilize and give less headaches when it comes to getting it to fully print/prime again.
19. You will now need to prime your cartridges/printer. You can print color bars or other colorful graphics to get the inks to flow correctly. You will also likely need to perform several print head cleanings followed by several test pages to make sure the bars are all printing.  You might need to raise the DPI setting temporarily if you have banding while printing. But can soon reduce the DPI back to 720 usually.
20. Make certain that you have washed all tools completely, and store in a safe place until next use.

Please see the Epson site for any technical issues with your printer regarding the print head cleanings. We are not familiar with all the Epson printers. The manufacturer is always the best resource for accurate information on repairs and technical information.